Kune kusiyana uye kufanana pakati peSiRNA neMRNA
Chii chinonzi siRNA vs.miRNA?
Usati wanyatsonzwisisa nzira iyo siRNA uye miRNA yakafanana uye kuti yakasiyana sei, inobatsira kuziva zvavari. Zvose siRNA uye miRNA mapurotoriki anoshandiswa kuongorora zvakasiyana-siyana zvemazwi emagetsi. Zviratidzo zvepurotamu ndiko kuongorora mapuroteni ayo kushandiswa kwechikamu chepuroteni chepuroteni kunoongororwa kamwechete.
Kufambira mberi kwepakanisi kwakaita kuti kudzidza kwakadaro kuite.
Saka siRNA uye miRNA yakafanana kana yakasiyana here? Nhengo dzejeri dzichiri mubvunzo iwoyo, zvichienderana nezvaunokumbira. Dzimwe nzvimbo dzinonzwa sokuti siRNA uye miRNA zvinhu zvimwechetezvo, asi vamwe vanoratidza kuti ivo vari masangano akasiyana zvachose.
Kusabvumirana kunouya nekuda kwekuti zvose zviri zviviri zvakaumbwa nenzira imwecheteyo. Dzinobva kubva murefu RNA. Izvo zvose zviri zviviri zvinoshandiswa mu cytoplasm ne enzyme inonzi Dicer isati yava chikamu cheprotini yakaoma RISC. Mazinyeni mapuroteni anogona kuvandudza mutengo wekuita pakati pezvinyorwa zvehupenyu.
Kune Icho Chiedza Chechidiki Pakati Peviri
Iko kushandiswa kweRNA kuipesana (RNAi) kunogona kuenzaniswa ne- siRNA kana miRNA, uye kune kusiyana kwakanyanyisa pakati pezviviri. Sezvakataurwa, zvose zviri kushandiswa mukati memusero ne Enzyme Dicer uye zvinowanikwa muRISC yakaoma.
SiRNA inonzi inofanana neRNA inopetwa kaviri yakatorwa nemasero. Mune mamwe mazwi, inopinda mavector , akadai semavirusi. Mavhesi anomuka apo mazita emagetsi anoshandisa bits eDNA kuti aite kuti geni rive nemhuka yakashandurwa nemajini ( GMO ). DNA inoshandiswa mune izvi inonzi vector.
Kunyange zvazvo siRNA inofungidzirwa kuti inofanana neRNA inopetwa kaviri, miRNA isina tsvina.
Icho chinobva pakusagadzikana kweRNA kusagadziriswa, kureva kuti yakaitwa mukati memusero. Iyi RNA inowanikwa mukati memakumbo emakiromore makuru eRNA.
Zvishoma Zvimwe Kusiyana
Imwe misiyano pakati peSiRNA uye miRNA ndiyo iyo siRNA inowanzosunga zvakakwana kune mRNA inotarirwa mumhuka. Icho chakaenzaniswa zvakakwana kune zvakaenzana. Kusiyana neizvi, miRNA inogona kudzivisa kushandurwa kwemhando dzakawanda dzakasiyana-siyana dzeMRNA nokuti kuwirirana kwayo hakuna kukwana. Shanduro inoitika mushure mokunge mutumwa RNA achinjwa uye anosunga kune imwe nzvimbo pa ribosome. Mumiti, miRNA inowanzove yakanyatsorongeka zvakakwana, iyo inobatsira mRNA cleavage kupesana nekudzvinyirira kwekushandura.
siRNA uye miRNA vanogona kutora chikamu mu epigenetics kuburikidza nenzira inonzi RNA-induced transcriptional silencing (RITS). Epigenetics ndiyo chidzidzo chekudzivirira kwemafuro emhando dzisina kukodzera umo kusanganiswa kwe nucleotide yeDNA hakushandurwi asi kunoratidzwa semakemikari. Izvi zvinowanikwa kuDNA kana chromatin protini pashure pokudzoka. Saizvozvowo, zvose zviri zviviri zvinokosha zvinoshandiswa pakushandisa kurapwa nekuda kwebasa ravanotamba mukutonga geni kutaura.