Zvisinei, mienzaniso yose uye miedzo kusvika zvino inosanganisira somatic cell therapy .
Ndiko kuti, vanongoshandura chete genetics yemasero mune murwere kunze kwerudzi rwemumvu kana mazai evha.
Germline Gene Therapy Kunetseka
Gene therapy pamasero e germline inokonzera kukakavara kwakanyanya nokuti chero shanduko inogadzirisa (sezvo vana vanogamuchira DNA inoshandiswa). Izvi zvinoita kuti zviitike, somuenzaniso, kwete kungogadzirisa chiremera chemajini chinokonzera bubble boy syndrome mumurwere, asi kuti abvisewo kukanganisa zvachose mumarudzi akatevera emhuri iyoyo. Muenzaniso uyu hauna hutachiwana hwehutachiona asi pane vamwe vazhinji, somuenzaniso, chirwere chaHuntington kana Duchenne muscular dystrophy, iyo inowanzozivikanwa uye inogona, zvichiitika, inobviswa mumhuri dzine kutambura uku.
Kunyange zvazvo kubvisa chirwere zvachose mumhuri chinhu chakanakidza kubatsirwa, kunetseka ndechokuti, kana chimwe chinhu chisingafanoonekwi chinowanzoitika (zvakadai seyecemia iyo yakaiswa kune vamwe veboka rokutanga revana rakarapwa nokuda kwekudzivirira zvirwere zvekuzvidzivirira nejena kushandisa gene therapy approach) , dambudziko rezvechimiro rinopfuudzwa kune vana vasati vazvarwa vemarudzi anotevera.
Kunetseka pamusoro pekuparadzira geni therapy zvipembenene zvegermona kana kuti migumisiro yezvizvarwa kumangwana zvakatoita zvakakomba zvakakwana kukonzera kufungidzira kwe germine genetic therapy asi kukanganisa hakusi kwega bedzi.
Genetic Kubudirira Hakusi Kunetseka Iye zvino
Chimwe chinetseka ndechokuti kushandiswa kwemhando iyi kunogona kuzarura mukana wekuisa mazamu ega kuti ape maitiro anobatsira akaonekwa, akadai sekuwedzera kweuchenjeri, chimiro chekureba, kana mavara emeso chaiwo.
Zvisinei, kunetseka kwetsika kuburikidza nekushandisa teknolojia iyi yekugadzirisa maitiro ezvisikwa hakusi kunyanya kumubvunza mubvunzo unoshandiswa nesayenzi haina kunyatsoziva zvakakwana zve genetics inobatanidza nehuwandu hwemhando idzi dzakaoma hunoita kuti maitiro ekurapa aswededze kushandura chero ipi zvayo kunyange zvinogoneka panguva ino.
Nharo pamusoro peGermany Therapies uye Scientific Method
Mukupera kwema1990 pakanga paine huwandu hwekukurukurirana pamusoro pehutano hwe germine gene therapy uye nehutano hwemagariro hunofambidzana nawo. Paiva nenyaya dzakawanda dzinotaura nezvenyaya iyi muzvisikwa uye Journal of the National Cancer Institute. IAmerican Association for Kufambira Mberi yeSayenzi yakatongoronga Hurongwa hweHuman Germline Interventions muna 1997, apo vamiririri vesayenzi nevechitendero vaiita sevari kutarisa pane izvo zvinofanira kuitika kana kuti zvisingafaniri kuitwa, panzvimbo yeiyo chaiyo ye sayenzi panguva iyoyo.
Zvinofadza, asi, pane zvishoma zvekukurukurirana kwema germine therapy. Zvichida njodzi yaJesse Gelsinger, uyo akafa nekuda kweshoko rakakura remararamiro panguva yejeri therapy test muYunivhesiti yePennsylvania muna 1999, uye kukura kusingafanoonekwi kweukwepa nevana vanobatwa nehutachiona hwemumakumbo mumavambo a2000 hwakagadzira imwe nhanho yekuzvininipisa, uye yakabereka kunzwisisa kwakanakisisa kwekunyatsochenjerera nekugadzirisa nzira yekuchenjerera.
Kusimbiswa kwezvino kunoratidzika kunge kune zvimwe pakubudisa zvibereko zvakasimba uye nzira dzakasimba dzekuvaka pane zvinopesana nekusimudzira mhopepepe iri mberi kuti iwane zviratidzo zvitsva zvinoshamisa. Zvechokwadi, migumisiro inoshamisa ichaitika asi, kuti zvive nemishonga inobatsira uye yakachengeteka, dzakawanda zvakasimba, zvidzidzo, uye kazhinji kuongorora zvesayenzi zvakakosha.
Ramangwana Ringave Rakagadzirwa neGermanline Therapies
Sezvo kufambira mberi mumunda kunofambira mberi, zvisinei, uye hutachiona hwevanhu hunova hwakasimba, hunofanirwa, uye hunogara huripo, zvirokwazvo mubvunzo we germin therapies uchadzoka zvakare. Vakawanda vatotanga kutora zvikamu zvakajeka uye mazano pamusoro pezvinobvumirwa kana kwete. Semuenzaniso, chechi yeKaturike yakabudisa mazano akafanana neaya mazita ejene therapy inonzi yakakodzera.
Vashomanana vangave vasina kuchenjera zvokuti vanofunga nezvemajeri ekurapa maitiro nhasi anopa kunzwisisa kwedu kwakakwana kweyi nzira yakaoma kwazvo.
Kunyange zvazvo vanotsvakurudza muOregon vari kushingaira kutsvaga maitiro chaiwo e germline gene therapy iyo inongogadzirisa DNA yakavharwa mukati mitochondria. Kunyangwe basa iri, kunyange zvakadaro, rakashora kutsoropodza. Kunyangwe nekunzwisisa kwakanyanya kwemajenomic uye genetic manipulation kubvira pakatanga geni therapy test muna 1990, kuchine zvakawanda zvakashata pakunzwisisa.
Zvichida kuti, pakupedzisira, pachava nezvikonzero zvinokumanikidza kuita chirwere chemajeremine. Kugadzira mirayiridzo pamusoro pekushandiswa kwemajaya remagariro ehupenyu hupi mune ramangwana, zvisinei, ingangove yakagadzirirwa pane zvinyorwa. Tinogona kungofungidzira zvichange zvakaita ramangwana uye ruzivo. Mamiriro chaiwo, kana achisvika, achave akasiyana uye zvichida achachinja zvose maitiro uye mazano ezvesayenzi.