Top Top 10 Biologic Zvinodhaka muUnited States

Izvi Zvinodhaka Zviri Kuchinja Nzira Iyo Kurwara Kunotariswa

Biologics imishonga inogadzirwa nemakemikari akaoma anogadzirwa achishandisa michina, michero, kana masero emhuka. Mazhinji biologics anobudiswa achishandisa teknolojia yeDNA inogadziriswa. Iko dzimwe nguva kunonzi inonzi biopharmaceuticals kana madhiragi ehupenyu.

Biologics vakashandura kurapwa kwezvirwere zvakawanda zvakakomba uye zvisingaperi uye vakanyengedza zviduku-madhimoni madhiragi kunze kwepamusoro ekutengeserana. Rheumatoid arthritis, dzimwe kenza, uye chirwere cheshuga ine nhamba huru kwazvo yezvokurapa biologic dzakazvitsaurira. Biologics iri kuchinja nzira iyo vanachiremba vanobata mamiriro ezvinhu akafanana ayo akatambudza vanhu kwemakore.

Generic Biologics

Kunyange zvazvo mishonga yakawanda yemakemikari yakagadzirwa kubva kune mamwe makemikari, biologics inodhura zvakanyanya nekuda kwekugadzirwa kwayo kwakaoma. Nemhaka yekudhura kwavo kwepamusoro, kune chido chakakura chekushandura kwemishonga ye biologic, kunyanya gumi zvakanyorwa pasi apa. Makambani matsva emishonga anokanganisa kodzero yekugadzira zvinyorwa zvechimiro. Zvisinei, nokuti ivo vakaoma zvikuru kugadzira, pane zvinetso pamusoro pekwanisi yekugadzira zvisikwa zvose zvakachengeteka uye zvakavimbika.

Top 10 Biologics

Mishonga gumi yakanyorwa pasi apa yose yakanyanya kudarika dudziro yemari ye "blockbuster" inoshandisa mishonga seyo yakaita mari inodarika $ 1 bhiriyoni mugore rekutengesa.

Muna 2015, biologics yakatanga kutarisana nemakwikwi ezvinyorwa , kana biogenerics, apo Rituximab yakagadzirwa neDIDEC Pharmaceuticals pasi pezita rinonzi IDEC-C2B8 . [1] Chibvumirano cheU.S. chakabudiswa muna 1998 uye chakapera muna 2015. Humira akarasikirwa nekudzivirirwa kwepentent yake muna 2016 uye Remicade icharasikirwa nekudzivirirwa kwayo muna 2018.

Mifananidzo iri pasi apa ndeyekupedzisira yakawanikwa mazuva anogadzirwa kune chimwe chigadzirwa.

  • 01 Humira

    Mishonga inopesana nokuputika Humira haisi iyo chete inotengesa zvakanakisisa biologic; yakanga iri mishonga yakatengesa zvakanyanya munyika yose, pasinei nekirasi.

    Zviratidzo: Rheumatoid arthritis, plaque psoriasis, chirwere cheCrohn, ulcerative colitis, ankylosing spondylitis; psoriatic arthritis, polyarticular juvenile idiopathic arthritis

    Mugadziri: AbbVie, an Abbott Laboratories akavhara

    Global Sales muna 2015: $ 14 biliyoni

    Zita rechizvarwa : Adalimumab

    Kutanga musi: 2002

  • 02 Remicade

    Remicade yakatanga kugadzirwa naCentocor Ortho Biotech, iyo yava ikozvino Janssen Biotech, svondo reJohnson & Johnson.

    Zviratidzo: Rheumatoid arthritis, chirwere cheCrohn, ankylosing spondylitis, psoriatic arthritis, plaque psoriasis, ulcerative colitis

    Mutengesi: Johnson & Johnson / Merck & Co.

    Global Sales muna 2015: $ 5.78 mabhiriyoni

    Zita rechizvarwa : Infliximab

    Kutanga musi: 1998

  • 03 Rituxan

    Rituxan (rituximab) yakagadzirwa neDIDEC Pharmaceuticals pasi pezita rinonzi IDEC-C2B8. Rituxan ikozvino inotengeswa muUnited States nechechi yeBioogen Idec neRoche Genentech.

    Chiratidzo: Kwete-Hodgkins lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis

    Mukonzi: Roche

    Global Sales muna 2015: $ 7.32 mabhiriyoni

    Zita rechizvarwa : Rituximab

    Kutanga musi: 1997

  • 04 Enbrel

    Etanercept yakagadzirwa nevatsvakurudzi veIndunex. Nhasi mishonga iyi inotengeswa muNorth America naAmgen naPfizer, naTaceda Pharmaceuticals muJapan uye naWedeth kune dzimwe nyika.

    Chiratidzo: Rheumatoid arthritis, plaque psoriasis, psoriatic arthritis

    Mutori: Pfizer / Amgen

    Global Sales muna 2016: $ 23 biliyoni

    Zita rechizvarwa : Etanercept

    Kutanga musi: 1998

  • 05 Lantus

    Lantus yakagadzirwa paSanofi-Aventis's biotechnology nzvimbo yekutsvakurudza muFrankfurt-Höchst, Germany.

    Chiratidzo: Chirwere cheshuga

    Mutori: Sanofi

    Global Sales muna 2015: $ 6.98 mabhiriyoni

    Zita rechizvarwa : Insulin glargine [rDNA origin] injection

    Kutanga musi: 2000

  • 06 Avastin

    Apo yakatangwa muna 2004, Aventein yaGenentech yaiva imwe yemishonga inodhura zvikuru pamusika, ine $ 4 400 pamwedzi mutengo.

    Chiratidzo: Breast, colorectal, itsvo, isina-duku-cell mapapu, glioblastoma, kenza yevana

    Mukonzi: Roche

    Global Sales muna 2015: $ 6.95 mabhiriyoni

    Zita rechizvarwa : Bevacizumab

    Kutanga musi: 2004

  • 07 Herceptin

    Herceptin yakagadzirwa naGenentech, ikozvino iri Roche, uye University of Californa-Los Angeles 'Jonsson Comprehensive Cancer Center.

    Chiratidzo: HER2 + kenza yemazamu

    Mukonzi: Roche

    Global Sales muna 2015: $ 6.59 mabhiriyoni

    Zita rechizvarwa : Trastuzumab

    Kutanga musi: 1998

  • 08 Neulasta

    Chiratidzo: Neutropenia ine chokuita nekenza chemotherapy

    Mutori: Amgen

    Global Sales muna 2016: $ 4.6 mabhiriyoni

    Zita rechizvarwa : Pegfilgrastim

    Kutanga musi: 2002

  • 09 Lucentis

    Yakagadzirwa naGenentech, ranibizumab, injectable, inotengeswa muUnited States neGenentech neNovartis kunze kweU.S.

    Chiratidzo: Kusangana-nehutano hwehutano hwemakore

    Mutori: Roche, Novartis

    Global Sales muna 2015: $ 4.2 biliyoni

    Zita rechizvarwa : Ranibizumab

    Kutanga musi: 2006

  • 10 Avonex

    Avonex inotengeswa muUnited States neBiogen Idec uye naMerck pasi pezita rezita Rebif.

    Gemany's Fraunhofer Institute for Interfacial Engineering uye Biotechnology IGB neCinnaGen Company yakagadzira Interferon beta-1a uye kubva muna 2006 mushonga wakatengeswa seCinnoVex, biosimilar, kuIrish.

    Chiratidzo: Multiple sclerosis (MS)

    Mutori: Biogen Idec

    Global Sales muna 2014: $ 3 biliyoni

    Zita rechizvarwa: Interferon beta-1a

    Kutanga musi: 1996

  • Anopikira biologics mune pipeline:

    Iko kune zvakawanda zvehupenyu hwehupenyu hwehupenyu huripo, kusanganisira mishonga yekurapa maranoma nemamwe makondombera. Sanofi uye Regeneronhave vakaparadzana kuti vadzidze Alirocumab, a monoclonal antibody ekurapisa hypercholesterolemia. Janssen akagamuchira "maitiro" eDAA ekurapwa kwekugadzirwa kwehuwandu hwehupenyu hwangu, Daratumumab, monoclonal antibody. Merck akawanawo kurapwa kwekodzero kunyorerwe na FDA yeMK-3475, mutezo weMonoclonal, wakagadzirirwa kuve nemapiranoma akapfuura uye mamwe makondombera.